CorMatrix® Cardiovascular, Inc. Secures Twelve (12) Additional U.S. Patents for ECM® Biomaterial CorMatrix® Bolsters Its Existing Patent Protections with Newly Issued Patents

Roswell, GA—March 4, 2015. CorMatrix® Cardiovascular, Inc., a leading developer of biomaterials and medical devices, today announced the issuance of U.S. Patent Numbers: 8,568,761; 8,753,885; 8,734,841; 8,642,084; 8,771,737; 8,734,842; 8,753,886; 8,735,155; 8,771,737; 8,784,891; 8,785,197 and 8,785,198 directed to CorMatrix’s novel augmented extracellular matrix (ECM®) bioscaffolds.

The augmented ECM® bioscaffold tissue structures comprise various materials, including, but not limited to, small intestine, urinary bladder, liver, stomach, placental, and heart tissue, that are augmented with a variety of selective bioactive components, such as GAGs, FGF-2, TGF-α, TFG-β, VEGF, cytokines and DNA. The augmented ECM® bioscaffolds, when administered to damaged tissue, induce stem cell proliferation and differentiation of stem cells into cardiomyocytes and, thereby, angiogenesis and remodeling of the damaged tissue.

“Since our founding in 2001, CorMatrix has focused on bringing innovation to the science of ECM® and ECM® technologies. Our success in securing these patents will help us to expand the effectiveness, scope, and potential of ECM® while guiding us in other restorative tissue advancements. We continue to pursue these and other patents globally with the intent of creating innovative healthcare products patients receive as part of their treatment, and the ultimate goal of improving their quality of life,” said David Camp, CEO and co-founder of CorMatrix.

With this and other significant patent protection, CorMatrix is poised to successfully expand its current line of product offerings with over 230 pending U.S. and foreign patent applications directed to various ECM® based compositions and structures.   In addition to the recently issued patents for CorMatrix’s novel augmented injectable extracellular matrix (ECM®) bioscaffolds, in the last two years alone over thirty (30) U.S. and foreign patents have issued for CorMatrix’s ECM® based compositions and structures, including U.S. Patent Nos. 8,871,511, 8,778,012, 8,758,448, 8,709,076, 8,257,434, 8,409,275, 8,679,176, 8, 449,607,8,608,796, 8,696,7448,845,719, 8,808,363, D718,862, D718,863, D718,864D694,408, D688,372, European Community Pat. Nos. EC 002455907-0001, European Community Pat. Nos. EC 002455907-0002, Japan Pat. Nos. JP 1514306, JP 1514307, and South Africa Pat. No. ZA 2011/06165.