CorMatrix® CanGaroo®

CorMatrix® CanGaroo® Envelope is intended to securely hold cardiovascular implantable electronic devices (CIEDs) such as pacemakers and defibrillators, creating a stabilized environment that enhances patient comfort and restricts migration.

The CanGaroo® conforms to the implantable device and remodels into a defined, vascularized pocket that supports and reinforces, while restricting migration of CIEDs. Its soft, supple edges enhance patient comfort, facilitate implantation, and simplify removal for exchanges or revisions. The CorMatrix CanGaroo® is designed to address the needs of physicians implanting CIEDs in their daily practice.

Foreign Body Response vs. Healing Regeneration

When a foreign body is implanted, monocytes infiltrate the site and are often converted into inflammatory M1 macrophages*.  This can result in fibrotic scar formation. CorMatrix ECM is a natural biologic that triggers a healing, regenerative M2 cascade*.

M1M2chart_780x300

*Data on file

Benefits

  • CanGaroo device remodels into systemically connected vascularized tissue
  • Stabilizes CIED to restrict migration
  • Supports and reinforces the pocket
  • May ease CIED removal from pocket during exchange or revision
  • Vascularized tissue pocket may enhance patient comfort
  • Soft, supple pocket has no sharp edges
  • CorMatrix CanGaroo conforms to the implantable device
  • CorMatrix ECM resists calcification

Implantation Timeline

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*ECM-Based Materials in Cardiovascular Applications: Inherent Healing Potential and Augmentation of Native Regenerative Processes Anna V. Piterina, Aidan J. Cloonan, Claire L. Meaney, Laura M. Davis, Anthony Callanan, Michael T. Walsh and Tim M. McGloughlin. Centre for Applied Biomedical Engineering Research (CABER), Department of Mechanical & Aeronautical Engineering, and Materials and Surface Science Institute (MSSI), University of Limerick, Limerick, Ireland. Int. J. Mol. Sci. 2009, 10(10), 4375-4417; doi:10.3390/ijms10104375
*Exploring the full spectrum of macrophage activation David M. Mosser and Justin P. Edwards, Department of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland 20742, USA. Nat Rev Immunol. 2008 December ; 8(12): 958–969. doi:10.1038/nri2448.
*Antibacterial Activity within Degradation Products of Biological Scaffolds Composed of Extracellular Matrix Ellen P. Brennan, et al. Tissue Eng. 2006 Oct; 12(10):2949-55.

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